SLA 처리 티타늄 표면에서의 유전자발현에 대한 상온대기압 플라즈마의 효과
Effects of non-thermal atmospheric pressure air plasma on gene expression at SLAtreated titanium surfaces
서혜연, 강민경, 최유리, 권재성, 최은하, 김경남,
소속 상세정보
서혜연 ( Seo Hye-Yeon ) - 연세대학교 치과대학 치과생체재료공학교실
강민경 ( Kang Min-Kyung ) - 한서대학교 치위생학과
최유리 ( Choi Yu-Ri ) - 연세대학교 치과대학 치과생체재료공학교실
권재성 ( Kwon Jae-Sung ) - 연세대학교 치과대학 치과생체재료공학교실
최은하 ( Choi Eun-Ha ) - 광운대학교 바이오플라즈마 연구센터
김경남 ( Kim Kyoung-Nam ) - 연세대학교 치과대학 치과생체재료공학교실
KMID : 1035320150420010015
Abstract
Dental implants manufacturers have developed high hydrophilic and rough implant surfaces which in turn exhibited better osseointegration than conventional ones. Based on in vitro studies, sand blast, large grit, acid etching(SLA)-treated surfaces with microstructural characteristics may promote the process of osseointegration. But when the SLA surface is kept dry in the air, it becomes hydrophobic. Appropriate non-thermal atmospheric pressure air plasma jet(air-NTAPPJ) processes render surfaces hydrophilic. The purpose of this research is to air-NTAPPJ on SLA surface treatment to improve the osteogenic functionality. The experiment was carried out through the a cytotoxicity assay and real-time reverse transcriptase-polymerase chain reaction(RT-PCR). The results were that the cell viability and gene expression of ALP, OCN, OPN, and Runx-2 of rMSC enhanced by air-NTAPPJ treated. Thus, air-NTAPPJ application can lead to an improved osseointegration.
키워드
atmospheric pressure plasma; SLA-treated surface; osseointegration
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